Rational design of GPCR biased Ligand

GPCR is one of druggable target. GPCR activation controls many networks of signaling pathways, which for most receptors are mediated by both G proteins and beta-arrestins. Different signaling pathways give different effects. To avoid side effects from G protein signals, designing beta-arrestins selective ligand is useful strategy for drug discovery. And there are lots of

API for opentargets

Association of drug targets with diseases are important information for drug discovery. There are lots of databases to provide these information I think. I like python. ;-) So, I am interested in following article. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210543/ Opentargets is a ” a data integration and visualization platform that provides evidence about the association of known and potential