Data analysis of MMP “from OR to Fluorine” #memo #journal

Control lipophilicity is key strategy for drug design. Medicinal chemist often struggle to ADMET issue due to their compound lipophilicity. Sometime ADMET issue can be improved by reducing LogD but it cause loss of potency. Matched molecular pair approach is used to find bioisosteric replacements that mean the substructure replacement with keeping potency but changeContinue reading “Data analysis of MMP “from OR to Fluorine” #memo #journal”