Rationalize of none additive SAR #memo #journal

In medicinal chemistry, chemists often make compound analogue which differ only a part. Optimization of R1, R2 etc… After optimized each R group, combination strategy is tried because it is expected that combination make additive effect for potency. But sometime combination strategy doesn’t work well. To understanding the phenomenon structural information is important. And recentlyContinue reading “Rationalize of none additive SAR #memo #journal”