Process development of fluorinated-pyrrolidin analogue #memo #organic_chemistry

Here is an interesting article for efficient synthesis of fluorinated pyrrolidin synthesis from pfizer.https://pubs.acs.org/doi/abs/10.1021/acs.oprd.9b00245 Fluorine containing building blocks are often used medicinal chemistry. So efficient synthetic route is very useful for us. Some years ago, I synthesized similar compounds 1-fluoro-2-amino cyclic amine derivatives. I tried to use almost same synthetic scheme described in scheme1. 1)