Do Pharmas need more data for building better model? #memo #medchem

Is ‘AI’ & ‘BidData’ key for success? Recently many pharmaceutical companies are trying to use AI for their drug discovery project acceleration and cost reduction. However sometime it fails because of lack of training data. It is rare that lots of data is available in early drug discovery projects. It is still difficult to build accurate predictive model with small data set.

Recently attractive project is reported in nature reviews drug discovery.
https://www.nature.com/articles/d41573-019-00120-w

The project named MELLODDY(Machine Learning Ledger Orchestration for Drug Discovery) which is an an €18-million, 3-year IMI project.

According the following URL, the MELLODDY consists 17 partners. And the partner will share about the structure and activity data without IP.
https://www.janssen.com/emea/new-research-consortium-seeks-accelerate-drug-discovery-using-machine-learning-unlock-maximum

  • 10 pharmaceutical companies: Amgen, Astellas, AstraZeneca, Bayer, Boehringer Ingelheim, GSK, Janssen Pharmaceutica NV, Merck KgaA, Novartis, and Institut de Recherches Servier
  • 2 academic universities: KU Leuven, Budapesti Muszaki es Gazdasagtudomanyi Egyetem
  • 4 subject matter experts: Owkin, Substra Foundation, Loodse, Iktos
  • 1 large AI computing company: NVIDIA

The consortium uses Amazon web services for machine learning. I think it is nice approach for data and model management and it will be difficult for pharma in Japan (just my personal opinion)…..

How about the chemical space of the combined compounds data? The data is enough for overcoming the applicability domain?

I hope the project goes well.

Advertisements

One thought on “Do Pharmas need more data for building better model? #memo #medchem

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.