Change properties of approved oral drugs

When I learned drug discovery long time ago, I read the article about Role of five which is a rule of thumb to evaluate druglikeness. https://www.sciencedirect.com/science/article/pii/S0169409X00001290?via%3Dihub You can read nice review about the druglikess scores in following URL. ( Written in Japanese ;-) ) View at Medium.com By the way, recently there are many articles