Applicable Domain on Deep Neural Networks #JCIM #chemoinformatics

I read interesting article from JCIM. Dissecting Machine-Learning Prediction of Molecular Activity: Is an Applicability Domain Needed for Quantitative Structure−Activity Relationship Models Based on Deep Neural Networks? URL is below. https://pubs.acs.org/doi/10.1021/acs.jcim.8b00348 The pros of DNN is feature extraction. And there are many articles which use DNN for molecular activity prediction. BTW, is it true that