Do we need measure metabolic stability in chiral form?

Recently the importance of rsp3 ratio is increasing because of accessing designed space, improving physchem properties such as solubility etc. However, accessibility of chiral compound is difficult due to synthetic accessibility or lack to chiral separation conditions. As you know, sometime biological activity is quite different between enantiomers. It is as same as ADMET properties.Continue reading “Do we need measure metabolic stability in chiral form?”

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