I have been working at a pharmaceutical company as MedChem for over 10 years. The progress of science is remarkable, there are lots of technologies in these area. But Drug Discovery project is still challenging area I think.
An article In nature reviews drug discovery analyzed the reason of failures in Phase II and III. It was informative for me.
The author analyzed the reason of failures for the period 2013-2015. Fig 1 shows reason for clinical trial failures 2013-2015. The primary reason of failure in Phase II and III is “Efficacy” ! I think it shows difficulty of translational research. It is hard to translate rodent to human. Second reason is safety in PhaseII and PhaseIII. The proportion of safety reason decreased in the period 2013-2015 compared with the period 2008-2010 in PhaseIII.
Medicinal Chemistry is challenging work.