Hit triage, case of MTase

I often see keyword “PAINS” in literature . Frequent hitters of HTS deck are problematic and PAINS filter is useful to remove them because false positives are time and cost consuming. Researcher of Lilly, reported nice letter in J. Med. Chem. Lett. http://pubs.acs.org/doi/abs/10.1021/acsmedchemlett.5b00375 The author analysed there HTS campaign of Methyltransferases( MTase ). They screenedContinue reading “Hit triage, case of MTase”