review for kinetics

I found nice review about kinetics of drug binding and residence time.
http://www.ncbi.nlm.nih.gov/pubmed/25782745

To improve in vitro, in vivo potency, I some time try to get SKR for designing molecule.
If I got correlation only residence time and lipophilicity or molecular weight, the information is not so good.
Because too liphophilic or heavy molecule is not so drug like.
So, I’m thinking about what is the best way to using kinetic data.
In this review, there are some example about how to use kinetic data for molecular design.

I was interested in Table1, because there are a lot of examples that are using SPR for kinetic data analysis.
Sometime I think analysis of kinetic using SPR is difficult because of instability of target protein or another factor but lots of success stories are. Hmm.

SKR is attractive for me as same as SAR, but rational design of molecule using kinetic data is still challenging area for me.

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s